OpenDNS has recently released a preview version of their DNSCrypt solution MAC and Windows to address both security and privacy concerns with traditional DNS.
I don't know about the technical merits of their SecureDNS product. Depending on the size of your network/organization and your budget, it may or may not be a good choice, but I'd comarison shop with competitor's products. Susan Bradley (AKA Ebitz Diva) the SBS expert who used to post here on occasion (she has her own blog now) has complained in her posts in the last year about OpenDNS raising their prices quite a bit for the SMB market products they now offer (we are talking a from subscriptions of less than $100/yr US to several hundred dollars). If you are a medium or large organization, the associated costs on a per user basis may be less of an issue.
Jim Adgate
James Adgate, CISSP IT Auditor and Compliance Specialist Data Loss Prevention (DLP) IT Security Policy and Risk Mitigation for Enterprises http://linkedin.com/in/jamesadgatech